Video presentation notes: Role of the Heme Oxygenase 1 In Modulating Inflammation After Insect Bites

 

Role of the Heme Oxygenase 1 In Modulating Inflammation After Insect Bites, uploaded 22 Sept. 2021 - presenter not identified

10:20 feral dogs as reservoirs for Leishmania 11:554 bite site microenvironment - vector gut microbiome, parasite derived exosomes 12:35 diagram of skin, immune cells 15:42 study aims 19:38 HO-1 production is a universal host skin response to blood feeding (hematophagous) arthropods 20:25 poking with needle does not provoke same response 22:51 Anophelese gambiae did not promote significant ischemic hemorrhage in tissue, but still increased HO-1 production in skin 31:01 inflammatory monocytes could be involved in erythrophagocytosis; in response to heat can differentiation into iron recycling macrophages 34:50 in situ confocal imaging of erythrophagocytosis in skin 36:16 HO-1 expressed both in cytopplasm and in nucleus 40:50 HO-1 promotes disease tolerance and reduces pathology, does not affect parasite replication or parasite load 41:37 Transient inhibition of HO-1 dysregulates inflammatory reaction 43:46 Neutrophils are main source of IL-1beta in Phlobotomus dubosci infected bites; inflammasome activation 44:26 treating sandflies with antibiotic prevents inflammasome activation, neutrophil infiltration and parasite dissemination to the spleen 46:46 carbon monoxide suppresses production of IL-1beta by neutrophils at the bite site; use of CORM-2 as CO donor 48:07 summary

 

Article: https://www.cell.com/cell-reports/pdf/S2211-1247(20)31306-1.pdf 

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