Posts

Showing posts with the label space medicine

geomagnetic fields, space, heart rate variability, autoimmune disease - brief notes

Two mind-blowing articles on the effects of geomagnetic field fluctuations on human health, published in highly ranked peer-reviewed journals. Otsuka et al. (2019) Anti-aging effects of long-term space missions, estimated by heart rate variability  https://www.nature.com/articles/s41598-019-45387-6 "Exposure to variable magnetic fields in space resulted in an increase in several HRV endpoints, suggesting that aging may also be slowed down in astronauts in space, as it was for Caenorhabditis elegans 18 . By contrast, our previous 1998–2000 studies (during solar cycle 23) in a subarctic area indicated that magnetic storms, which involved larger magnetic disturbances than those observed during ISS01 and ISS02, suppressed HRV indices in 19 clinically healthy subjects 24 . The decrease in HRV was statistically validated for TF (−18.6%, P = 0.00009), primarily contributed to by VLF (−21.9%, P < 0.000001) in conjunction with ULF (−15.5%, P = 0.00865) and LF (−14.2%, P = 0.001

brief notes - doxycycline, TGF-beta, microgravity

The topic of low dose doxycycline (DOX) for Parkinson's came up on a forum. Rationale for its use in PD is typically based inhibition of a-syn aggregation , however DOX is a matrix metalloproteinase inhibitor (2 and 9). Matrix metalloproteinases are a group of enzymes that break down collagen and some other extracellular matrix proteins. White tea is supposed to be good for preventing skin aging since it contains a substance that inhibits one or two matrix metalloproteinases (can't remember which ones). The extracellular matrix is the stuff in between cells and it is mostly collagen. A lot of TGF-beta, a signalling molecule involved in the immune system, is localized in the ECM and engages in 'solid state' signalling - it is not dissolved in fluid, it stays put and interacts with cells as they come in contact when the tissue is deformed by mechanical pressure or cells migrate . People with connective tissue disorders often have immune system problems because