Another Epidemiological Study Finds Glucosamine Associated with Reduced Mortality
Glucosamine (credit: AndresJS ) Sometimes I lurk on various life extension message boards and am perplexed that many (most?) people do not list glucosamine in their pro-longevity 'stack' even though its use is associated with reduction in all-cause mortality. Glucosamine is cheap and relatively well-tolerated. While association does not mean causation, the relationship has been found in several large epidemiological studies and holds up when controlling for various demographic factors; similar associations have not been found for other supplements - not even fish oil or vitamin D. There are some plausible mechanisms, which I don't have time to really get into, unfortunately. In brief, glucosamine inhibits glucose metabolism (see Ristow interview linked below) - which could have direct effects and also effects via the gut microbiome, increases hyaluronic acid production, and may have other effects relating to O-GlcNAcylation (that's what I'm most interested i