Glucose - effects on survival in Listeria and influenza infection
[2020-07-03] Presentation by Ruslan Medzhitov from 2018 titled "Inflammation and Disease Tolerance: Surviving Acute Illness" 1:25 cost of inflammation and cost vs. benefit trade-off 4:01 sickness behaviors, includes loss of appetite - observed in all animals including insects 5:10 Decreased Food Intake After Listeria Infection - disease induced anorexia 6:32 Anorexia Protects Against Listeria Infection (survival rate) 7:43 Glucose is Sufficient for Lethality in Listeria Infection - even at only 2% of normal caloric intake 8:26 2DG (inhibits metabolism of glucose) increased survivorship (100% survival vs. 50% without 2DG) 9:06 Effects of Feeding on Sepsis Survival - sepsis model using lipopolysaccharide (LPS) injection - same results found for feeding, glucose and 2DG experiments 11:10 Effects of Glucose in LPS Sepsis is Independent of Magnitude of Inflammation 11:48 Mechanism for Glucose-mediated Death in Bacterial Inflammation - review of fasting metab