Video Notes: Mast Cell Activation Syndrome - Making the Difficult Diagnosis with Dr. Tania Dempsey



Mast Cell Activation Syndrome - Making the Difficult Diagnosis with Dr. Tania Dempsey (interviewed by Dr Michell, channel - The Smartest Doctor in the Room)

uploaded 19 May 2022

18:00  breast implants & other surgical implants, dental implants as MCAS triggers  

20:45  diagnostic testing for MCAS 

 21:38  blood markers - histamine, chromogranin A, tryptase, heparin  

22:39  24-hour urine metabolites - N-methylhistamine, prostaglandin D2, leukotrienes, 2,3-Dinor-11beta-prostaglandin F2 alpha  

23:01  CD117 marker staining of tissue biopsy samples (endoscopy or colonoscopy) ; mast cell count  

26:00  eosinophilic esophagitis, comparison w/ recognition of disease; many EoE pts have MCAS {comment: it's my understanding that mast cells recruit eosinophils} 

 28:17  Bartonella, need to treat underlying causes of MCAS 

 29:24  vitamin D receptors on mast cells  

30:12  problem of excipients in medications and supplements  

31:08  improvement in neurologic symptoms by stabilizing mast cells in gut, use of cromolyn sodium, H2 blockers, probiotics  

33:04  baking soda can prevent hypersensitivity reactions, case study of exercise induced anaphylaxis after eating wheat prevented by drinking sodium bicarbonate solution 

 { question: would use of proton pump inhibitors, which can abolish alkaline tide, increase food allergy reactions? what about H2 blockers - if they blunt alkaline tide, does that reduce their effectiveness? should H2 blockers always be paired with H1 blockers?} 

 37:30  long covid & mast cells  

40:54  long covid - viral persistence, reactivated Lyme 

 42:29  vaccines vs. boosters  

45:07 new therapeutics - SOT - supportive oligonucleotide technique - antiviral, antibacterial, cancer treatment (aka antisense therapy) 

 49:54  Dr Dempsey's websites, social media & contact information

 

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