Creatine, Asthma and Allergies
Creatine can exacerbate airway inflammation and asthma: Effect of Creatine Supplementation on the Airways of Youth Elite Soccer Players [2019] https://pubmed.ncbi.nlm.nih.gov/30913162/ Creatine Activates Airway Epithelium in Asthma [2010] https://pubmed.ncbi.nlm.nih.gov/21072743/ "Inducible nitric oxide synthase (iNOS) is an isoform of NOS, and increases in its expression have been linked to eosinophilic inflammation and airway remodelling in asthma... we found that creatine supplementation was associated with greater epithelial expression of iNOS and NF- κ B in both non-sensitized and sensitized mice (Fig. 3 a, b ), which could be considered a possible mechanism for the Cr-induced asthmatic phenotype." The increase in iNOS may have something to do with creatine's effect on arginine metabolism, though in macrophages, it looks like creatine reduces iNOS (?) : Creatine shapes macrophage polarization by reprogramming L-arginine metabolism [2019] - https://www.jimmunol.or