The Rhyothemis princeps Brain Externalization Project

  A brief review on how statins could be used to treat immune thrombocytopenia (ITP), an autoimmune disease: Nazy and Cuker (2018) - Statins for high cholesterol … and for low platelets? - https://doi.org/10.1182/blood-2018-01-824888 "Megakaryocytes in ITP patients show impaired maturation and signs of degradation due to defects in the megakaryocytes and their environment. 7   Among the cells in the BM [bone marrow] niche implicated in supporting megakaryopoiesis and thrombopoiesis are the BM EPCs [endothelial progenitor cells], ... Treatments that induce platelet production by enhancing the BM microenvironment could be beneficial for corticosteroid-resistant ITP. Atorvastatin is a widely used drug for the treatment of primary hypercholesterolemia and mixed dyslipidemia by inhibiting 3-hydroxy-3methyl-glutaryl-coenzyme A reductase. Among its activities, it is known to improve the mobilization and function of EPCs. Recently, Shi et al showed the effectiveness of atorv...

Yesterday Lifespan.io reported on a finding by Wen et al. (2021) that vibration at 90 Hz reduced cellular senescence in bone marrow mesenchymal stem cells; from the news article's conclusion: https://www.lifespan.io/news/vibration-reduces-cellular-senescence-in-the-bones-of-rats/ "Further, while maintaining bone density is crucial to extending healthspan, vibration does not seem to be a great candidate as an anti-aging therapy. One of the greatest advantages of a longevity-based approach is its application to all the tissues in the body, and while the authors of this study did not investigate the effect of vibration on other organs, it seems logical that these effects would apply only to bone tissue."  Original research article: https://www.aging-us.com/article/202907/text  However - https://pubmed.ncbi.nlm.nih.gov/16364518/ “Longstanding evidence that bone formation and resorption are required for the development of haemopoietic marrow strongly suggests that ost...