Lon protease
[2020-06-13] Talk by Kelvin J.A. Davies on Lon protease from 2013(?) 12:56 Degradation of oxidized proteins by proteasome is mostly ATP independent; degradation by Lon is ATP dependent 20:08 the most decreased mRNA in skeletal muscle in mice in aging is Lon 20:36 the main one that comes up is aconitase, but there are many, many others 20:17 Lon inducibility is diminished in senescent cells & they have more carbonylated proteins 22:20 slide - Aging Decreases Lon Induction and Stress Protection 26:28 Lon attaches to mtDNA and allows for biogenesis; under stress it detaches and degrades oxidized proteins and at that point proliferation stops 28:59 Lon is inducible by H2O2, heat stress, starvation, cold stress, mechanical shear stress, peroxynitrite Also, loss of frataxin upregulates Lon and ClpP proteases and results in too much degradation of Fe-S proteins [1]. 1 - Guillon, Blanche, Anne-Laure Bulteau, Marie Wattenhofer-Donzé, Stéphane Schmucker, Bertrand Friguet,