The Rhyothemis princeps Brain Externalization Project

 Lemon balm ( Melissa officinalis ) was found to improve sleep in a fly model of Alzheimer's disease. Screening of sleep assisting drug candidates with a Drosophila model (2020) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390450/   "Overall, female flies were more vulnerable to DD stimulation considering total sleep time, but not in the sleep frequency. Therefore, female flies were chosen for the following drug screening study. ... the administration of melatonin shortened sleep latency but did not increase the total sleep time during sleep deprivation ( Fig 4A, 4B and 4F ), indicating that melatonin may only induce flies to sleep faster but not longer. Such results are consistent with human clinical trials that have reported that the prescription of melatonin helps induce sleep but does not enhance total sleep time [ 4 ]. Moreover, the activity index shows no change after melatonin treatment ( Fig 4G ), suggesting that melatonin has a limited effect on activity during wake

  https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awab054/6242260  "Animal studies suggest that noradrenergic fibres from the locus coeruleus play a key role in providing trophic support for both astrocytes and neurons, and in suppressing inflammation and oxidative stress. 19 Control of microvascular flow by the noradrenergic locus coeruleus might provide part of this trophic support by helping to match oxygen availability to cellular oxidative phosphorylation in brain tissue."   https://pubmed.ncbi.nlm.nih.gov/23426667/ "Our data demonstrate that stimulation of the LC activates a broad network of cortical pyramidal cells and interneurons and concomitantly increases cortical perfusion. The hyperemic response virtually disappeared after selective lesioning of the LC–NA system and required activation of α- and β-adrenoreceptors. In addition, the evoked CBF response to the LC–NA system required the release of glutamate and GABA likely from the