Notes - week of 2020/10/05

Autophagy and Neurodegeneration │ Prof. David Rubinsztein

 https://www.youtube.com/watch?v=BgIk9ehY09k

30:00 screening for mTOR independent autophagy inducing drugs

37:08 felodipine, a Ca channel blocker, induces autophagy and clears protein aggregates

46:00 vicious cycle of protein aggregates impairing autophagy -> more protein aggregates

~ 

Glycine and tryptophan lower uric acid levels in patients with mild hyperuricemia:

https://pubmed.ncbi.nlm.nih.gov/30845731/

Glycine is inversely correlated  with serum uric acid in healthy people and in lifestyle-related diseases:

https://www.nature.com/articles/s41598-017-17710-6

The Nature article also notes men are more likely to have hyperuricemia and that estrogen promotes uric acid excretion.

The SURE-PD trial of inosine to increase serum and CSF urate was halted due to lack of efficacy, BUT inosine was found to be effective in increasing urate and decreased rate of progression in women:

https://pubmed.ncbi.nlm.nih.gov/31484712/

Gelatin and collagen hydrolysates  are high in glycine; magnesium supplements are often in the form of magnesium glycinate.


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