Notes - week of 2020/9/21

Read a bit about lipid metabolism in PD

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099649/

"Since oligomers seem to be the toxic species rather than fibrils, we believe that the increasing DHA concentration in the cell could worsen toxicity rather than having a protective role."

oh dear

Eating fish is associated with reduced risk of PD - but maybe the benefit is from beta parvalbumin??

~

A clinical trial published in 2019 found omega-3 from flax plus vitamin E to be beneficial in PD - though of course flax does not contain DHA, but ALA which may be converted to DHA - but not very efficiently & there are sex differences (reproductive age women do so more efficiently than others)

https://www.sciencedirect.com/science/article/abs/pii/S0303846718304633

~

Seems like fibrates would be helpful, but one study in a rat models says no

https://pubmed.ncbi.nlm.nih.gov/28403913/

but brilliant blue G, a P2X7R anatgonist, was beneficial

~

Cereblon - "Our study reveals a novel role of CRBN and the underlying molecular mechanism in the regulation of misfolded proteins in neurodegenerative diseases, which may provide new insights for finding pharmacological targets for these diseases."

https://academic.oup.com/hmg/article/27/4/667/4764074

So back to my question about rodent models - since rodents have functionally different cereblon - shouldn't rodent models of neurodegenerative diseases be engineered to express human cereblon? 

~


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