LINE1 in reproductive aging, sodium in reproduction, gut bacteria can provide essential amino acids - brief notes on a video

 

Making Reproductive Longevity a Reality | Episode 3 - March 5, 2021

4:26 Start of Dr Ivana Celic on LINE1 retrotransposons in reproductive aging 
11:12 Impact of LINE1 on genome structure { holy moly }  
12:55 LINE1 mRNA can induce interferon response - inflammatory diseases and aging  
14:55 LINE1 and Germ Cells ; spermatogenesis 
17:31 LINE1 and fetal follicular atresia  
18:59 Aging and LINE1in somatic tissue - upregulation of LINE1 due to changes in chromatin and methylation status
29:09 Start of Dr Carlos Ribeiro on nutrients, neuronal circuits and microbiome ...  
38:31 Sodium (salt) is needed for reproduction 
43:24 gut bacteria in Drosophila can produce essential amino acids needed for reproduction
 https://www.nature.com/articles/s41467-020-18049-9

 
Comment:
50:32 re: salt consumption and preeclampsia  
One way to get around the problem might be miso, which contains sodium, but its consumption has been shown to not increase blood pressure generally (though not specifically in pregnancy). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313421/  
Miso consumption was found to be associated with lower risk of preterm birth: https://link.springer.com/article/10.1186%2Fs12199-019-0782-z 
 
 

Comments

Post a Comment

Popular posts from this blog

Notes - week of 2020/10/26

 Learned about PON1 and PD yesterday by attending web conference presentation by Beate Ritz: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922777/ Anthocyanins increase PON1 and are thought to protective against PD, but they also increase NO production - hmm .... ~ Vitamin D levels are decreased in PD: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267215/ "After the discovery that the VDR and 1α-hydroxylase, the enzyme that converts vitamin D to its active form, were highly expressed in the substantia nigra, it was hypothesized that inadequate levels of circulating vitamin D may lead to dysfunction or cell death within the substantia nigra ( 25 , 26 )." Active vit D (calcitriol) is mainly produced in the kidneys, as is klotho. a-syn is produced in the kidneys throughout lifespan.  ~ Chronic kidney disease prevalence is lower in PD patients: https://www.mdsabstracts.org/abstract/prevalence-of-chronic-kidney-disease-in-patients-with-idiopathic-parkinsons-disease-in-a-tertia
Read more

mouse models of menopause / reproductive aging in social insects - brief notes

Image
    Another in a great series of webinars by NUS Medicine. 5:10 Start of 1st presentation - Berenice A. Benayoun - Why we need age-relevant mouse models of menopause Ovariectomized mice are not good models of menopause.  10:43 Slide - comparison of post-reproductive lifespan among mammalian species 18:46 VCD injection; VCD is 4-vinylcyclohexene diepoxide, an environmental toxicant that causes ovarian failure 20:31 Genetic models - Foxl2 +/- ; Fshr +/- 25:00 Start of 2nd presentation - Ingrid Fetter Pruneda - The molecular and cellular basis of high fertility in social insects Queen ants manage to have extremely high fertility at the same time as longer lifespan relative to worker ants. 35:20 ant reproductive mode can be flexible; some species have cyclic castes - switching from queen to worker and back 51:54 Apart from sex organs,  liver is most sexually dimorphic organ - important implications for drug metabolism { Does this have implications for liver transplantation? }
Read more

Aconitase

Image
Aconitase (aconitate hydratase) is a tricarboxylic acid cycle (TCA) enzyme that converts citrate to iso-citrate via cis-aconitate. It has an iron sulfur cluster that interacts directly with substrate and is prone to oxidation by superoxide. Inactivation of aconitase has been  implicated in neurodegenerative diseases [1]. A mutation in ACO2 is associated with Infantile Cerebellar-Retinal Degeneration [2]. from [2] : "The active (4Fe-4S) cluster was shown to be extremely sensitive to superoxide-mediated inactivation 10 and a decrease in AH activity was observed in several neurodegenerative diseases associated with the development of oxidative stress, in particular Friedreich ataxia [MIM 229300 ], Parkinson [MIM 168600 ], and Alzheimer disease [MIM 104300 ], 11 as well as in mice lacking mitochondrial superoxide dismutase. 12 The reduced AH activity in endomyocardial biopsies of individuals with Friedreich ataxia was attributed not only to oxidative stress but also to the im
Read more

Freidriech ataxia - biochemical mechanisms

Image
Yesterday I watched two excellent presentations on Freidreich ataxia (still trying to use the proper nomenclature convention) from back in 2011: Notes: 5:44 frataxin is essential for muticellular eukaryotes (but not single celled organisms) frataxin is needed for the production of iron-sulfur clusters (aconitase is an important TCA enzyme that includes an iron-sulfur cluster that is particularly vulnerable to oxidation) 13:07 Indeed! & also part of the urea cycle 18:35 Reduction in frataxin leads to iron accumulation in the mitochondrion   38:26 summary of therapeutic approaches in relation to hypothetical vicious cycle in FA EPO - erythropoietin increases expression of genes related to iron utilization (lactoferrin and Wim Hof method breathing increase EPO) HDAC inhibitors increase expression of frataxin (butyrate / tributyrin are HDACi) pioglitozone increases mitochondrial biogenesis (PQQ & urolithin A do the same) I think neuroinflammation should be included as part
Read more