brief notes - senescent cell clearance, kidney type glutaminase, intracellular pH

New article on kidney type glutaminase and senescent cell clearance: https://science.sciencemag.org/content/371/6526/265 

related:

 Simultaneously Targeting Tissue Transglutaminase and Kidney Type Glutaminase Sensitizes Cancer Cells to Acid Toxicity and Offers New Opportunities for Therapeutic Intervention https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291776/ 

It's interesting that this all hinges on intracellular pH; there was a good talk on intracellular pH and neurodegeneration a while back: https://youtu.be/OUmFkfTFm_o

Comments

Post a Comment

Popular posts from this blog

Video Notes: Mast Cell Activation Syndrome - Making the Difficult Diagnosis with Dr. Tania Dempsey

Image
Mast Cell Activation Syndrome - Making the Difficult Diagnosis with Dr. Tania Dempsey (interviewed by Dr Michell, channel - The Smartest Doctor in the Room) uploaded 19 May 2022 18:00  breast implants & other surgical implants, dental implants as MCAS triggers   20:45   diagnostic testing for MCAS     21:38  blood markers - histamine, chromogranin A, tryptase, heparin   22:39   24-hour urine metabolites - N-methylhistamine, prostaglandin D2, leukotrienes, 2,3-Dinor-11beta-prostaglandin F2 alpha   23:01   CD117 marker staining of tissue biopsy samples (endoscopy or colonoscopy) ; mast cell count   26:00   eosinophilic esophagitis, comparison w/ recognition of disease; many EoE pts have MCAS {comment: it's my understanding that mast cells recruit eosinophils}     28:17   Bartonella, need to treat underlying causes of MCAS     29:24  vitamin D receptors on mast cells   30:12  pro...
Read more

Video presentation notes: Role of the Heme Oxygenase 1 In Modulating Inflammation After Insect Bites

Image
  Role of the Heme Oxygenase 1 In Modulating Inflammation After Insect Bites, uploaded 22 Sept. 2021 - presenter not identified 10:20 feral dogs as reservoirs for Leishmania 11:554 bite site microenvironment - vector gut microbiome, parasite derived exosomes 12:35 diagram of skin, immune cells 15:42 study aims 19:38 HO-1 production is a universal host skin response to blood feeding (hematophagous) arthropods 20:25 poking with needle does not provoke same response 22:51 Anophelese gambiae did not promote significant ischemic hemorrhage in tissue, but still increased HO-1 production in skin 31:01 inflammatory monocytes could be involved in erythrophagocytosis; in response to heat can differentiation into iron recycling macrophages 34:50 in situ confocal imaging of erythrophagocytosis in skin 36:16 HO-1 expressed both in cytopplasm and in nucleus 40:50 HO-1 promotes disease tolerance and reduces pathology, does not affect parasite replication or parasite load 41:...
Read more

Directory of STEM & Mastodon Instances

I've started a directory of STEM [science, technology, engineering and mathematics] and medical mastodon instances - mainly English language. Here's the link to the Google spreadsheet: https://docs.google.com/spreadsheets/d/1hZz1FB2HP-nqXNHigaiExFWvWTkMJ-TwYJa8W3Pdh-Q/edit?usp=sharing If you want to add to the form either request permission to edit through the form or you can message me: http://zeroes.ca/@Rhyothemis   I also have a list of Mastodon / FediVerse STEM and medical hashtags: https://docs.google.com/spreadsheets/d/1Alc8MlwDCziS6Z-CFij5A6A1MKQtGYTeO--xfW1vl6A/edit?usp=sharing    It's a shame what's happened with Twitter - it was great tool for rapid science communication and SciComm in general. I'm hoping more researchers find a new home in the FediVerse and make liberal use of hashtags so as to avoid siloing of information.
Read more

cold exposure & breast cancer

A recent flare up of fibrocystic breast symptoms had me wondering if use of cold packs has any effect on breast cancer (BC) risk. Cold packs are often recommended for mastalgia (breast pain) from fibrocystic breast disease, mastitis, engorgement due to breast feeding cessation, and post breast cancer surgery. Whole body cold exposure has been found to increase tumor growth and metastasis in mice: https://www.medicalnewstoday.com/articles/269266 T-cell function is diminished at colder temperature leading to reduced anti-tumor immune responses. The article notes implications for standard research practice of housing mice at relatively colder temperatures - another thing to add to the list of problems in current practices.  (Could cold acclimation be used to promote tolerance in autoimmunity and atopy? Another topic for another day.) The mice were subjected to whole body cold exposure  - not spot treatment. It is conceivable that reducing acute inflammation through localized cold...
Read more