Aquaporin Lecture Notes


"Aquaporin water channels - from transfusion medicine to malaria" by Dr. Peter Agre
Sept. 9, 2015

22:22 Rarity of AQP1 null mutants despite apparently limited effect on phenotype - at birth lung goes from being secretory organ to being absorptive, may be a critical point
25:46 AQP4 and blood brain barrier
{ not mentioned in lecture: Evidence that pericytes regulate aquaporin-4 polarization in mouse cortical astrocytes https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223569/ } 
26:54 AQP4 - accelerated brain damage 
27:49 in many cases or stroke the individual succumbs not to the infarct, but to brain edema
30:04 Aquaporins, stress response , decline in function with aging 
41:34 AQP7 and AQP9 - Glycerol Metabolism
AQP7 - present in fat; water & glycerol permeation; suppressed by insulin; releases glycerol from fat catabolism during starvation
AQP9 - present in liver; water, glycerol & urea permeation; facilitates hepatic glycerol uptake for gluconeogenesis 
42:29 AQP7 and AQP9 - Heavy Metal Permeation
43:29 aquaporins involved in detoxification & excretion of arsenic 
44:49 summary 
49:22 Question & Answer

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